https://scholars.lib.ntu.edu.tw/handle/123456789/560571
標題: | Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling | 作者: | KAI-CHIEN YANG Nerbonne J.M. |
關鍵字: | Arrhythmias; Cardiac hypertrophy; Diabetes; Heart failure; Long non-coding RNAs; MicroRNAs; Myocardial excitability; Transcription factors | 公開日期: | 2016 | 卷: | 26 | 期: | 3 | 起(迄)頁: | 209-218 | 來源出版物: | Trends in Cardiovascular Medicine | 摘要: | In the mammalian heart, multiple types of K+ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K+ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K+ channel diversity. Maladaptive remodeling of K+ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational, and epigenetic mechanisms contributing to regulating the expression, distribution, and remodeling of cardiac K+ channels under physiological and pathological conditions. ? 2016 Elsevier Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/560571 | ISSN: | 10501738 | DOI: | 10.1016/j.tcm.2015.07.002 | SDG/關鍵字: | lipid; long untranslated RNA; potassium channel; long untranslated RNA; potassium; potassium channel; atrial fibrillation; diabetes mellitus; epigenetics; gene expression; genetic transcription; heart disease; heart failure; heart infarction; heart muscle ischemia; heart ventricle hypertrophy; human; molecular mechanics; pathogenesis; physiological process; posttranscriptional gene silencing; priority journal; protein processing; regulatory mechanism; Review; action potential; cardiac muscle; gene expression regulation; genetics; heart atrium remodeling; heart disease; heart rate; heart ventricle remodeling; male; metabolism; pathology; pathophysiology; RNA processing; signal transduction; Action Potentials; Atrial Remodeling; Gene Expression Regulation; Heart Diseases; Heart Rate; Humans; Male; Myocardium; Potassium; Potassium Channels; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; Signal Transduction; Transcription, Genetic; Ventricular Remodeling |
顯示於: | 藥理學科所 |
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