https://scholars.lib.ntu.edu.tw/handle/123456789/566043
標題: | Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders | 作者: | Hung, W.-L. Ho, C.-T. MIN-HSIUNG PAN |
關鍵字: | dietary phytochemicals; neuroinflammation; neurological disorders; NLRP3 inflammasome | 公開日期: | 2020 | 卷: | 64 | 期: | 4 | 來源出版物: | Molecular Nutrition and Food Research | 摘要: | Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase-1-mediated interleukin-1β and interleukin-18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome-mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant-derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders. ? 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85075166497&partnerID=40&md5=0212ae2fa920449d0c73970b758e86c4 https://scholars.lib.ntu.edu.tw/handle/123456789/566043 |
DOI: | 10.1002/mnfr.201900550 | SDG/關鍵字: | cryopyrin; inflammasome; phytochemical; animal; chemistry; drug effect; human; metabolism; molecularly targeted therapy; neurologic disease; Animals; Humans; Inflammasomes; Molecular Targeted Therapy; Nervous System Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Phytochemicals |
顯示於: | 食品科技研究所 |
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