Human genetics of diabetes mellitus in Taiwan
Journal
Frontiers in Bioscience
Journal Volume
14
Journal Issue
12
Pages
4535-4545
Date Issued
2009
Author(s)
DOI
Abstract
Diabetes mellitus (DM) is a disease defined by biochemical hyperglycemia. Currently it is classified into four major categories: type 1 DM (T1DM), type 2 DM (T2DM), gestational DM (GDM) and other DM. Within each category, the etiology is still heterogeneous. The pathogenesis of most DM is multi-factorial, including many genetic and environmental factors. T1DM, T2DM and GDM are polygenic. In the category of other DM, there are at least six maturity onset diabetes of the young (MODY) and many other genetic syndromes associated with DM, which are monogenic in origin. In this review, we briefly summarized the current status of genetics in DM, described what has been done in this specific area in Taiwan and discuss what should be done after the era of genome-wide association study.
SDGs
Other Subjects
genetics; human; insulin dependent diabetes mellitus; medical genetics; mitochondrion; non insulin dependent diabetes mellitus; physiology; review; Taiwan; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Genetics, Medical; Humans; Mitochondria; Taiwan
Type
journal article