https://scholars.lib.ntu.edu.tw/handle/123456789/569682
Title: | Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study | Authors: | JANG-JAER LEE SHIH-JUNG CHENG Wang J.-J. CHUN-PIN CHIANG HAO-HUENG CHANG HSIN-MING CHEN SANG-HENG KOK |
Issue Date: | 2013 | Journal Volume: | 35 | Journal Issue: | 12 | Start page/Pages: | 1787-1795 | Source: | Head and Neck | Abstract: | Background: Studies concerning prognostic factors specific for alendronate-related osteonecrosis of the jaws (ONJ) are rare. Methods We surveyed a cohort of 100 osteoporotic patients with 111 alendronate-related ONJ lesions treated during a 4-year period. Prognostic values of clinical variables and serum markers of bone turnover were assessed by univariate and multivariate analyses. Results: The cumulative complete response rate at 6 months was 48.65%. Serum bone-specific alkaline phosphatase (BSAP) level >10 μg/L, lesion depth ≦ 10 mm, and lesions in anterior regions denoted a better chance of healing within 6 months and the adjusted hazard ratios were 2.48 (95% confidence interval [CI], 1.41-4.37), 2.71 (95% CI, 1.57-4.70), and 3.94 (95% CI, 1.87-8.30), respectively. Conclusions: Early discovery of lesions and prevention of their deeper extension are crucial for improving the prognosis of alendronate-related ONJ. A higher pretreatment level of BSAP indicates a better prognosis. ? 2013 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84888012333&doi=10.1002%2fhed.23235&partnerID=40&md5=4d8294fe496a8510adbf796b3d5a3746 https://scholars.lib.ntu.edu.tw/handle/123456789/569682 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.23235 | SDG/Keyword: | alendronic acid; alkaline phosphatase; amoxicillin; amoxicillin plus clavulanic acid; chlorhexidine; clindamycin; aged; article; bone turnover; cohort analysis; female; health survey; human; jaw osteonecrosis; major clinical study; male; priority journal; prognosis; treatment response; alendronate; BSAP; CTX; ONJ; osteoporosis; Adult; Aged; Aged, 80 and over; Alendronate; Alkaline Phosphatase; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Biological Markers; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Bone Remodeling; Chlorhexidine; Clindamycin; Cohort Studies; Collagen Type I; Debridement; Female; Humans; Male; Middle Aged; Mouthwashes; Multivariate Analysis; Osteoporosis; Peptides; Prognosis; Retrospective Studies |
Appears in Collections: | 臨床牙醫學研究所 |
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