https://scholars.lib.ntu.edu.tw/handle/123456789/581968
Title: | Hepatitis B virus infection and metabolic syndrome: Fact or fiction? | Authors: | Wang C.-C. TAI-CHUNG TSENG JIA-HORNG KAO |
Keywords: | Arteriosclerosis; Fatty liver; Hepatitis B virus; Insulin resistance; Lipid; Metabolic syndrome | Issue Date: | 2015 | Publisher: | Blackwell Publishing | Journal Volume: | 30 | Journal Issue: | 1 | Start page/Pages: | 14-20 | Source: | Journal of Gastroenterology and Hepatology (Australia) | Abstract: | Although hepatitis C virus infection is known to be linked with insulin resistance, dyslipidemia, and hepatic steatosis, the relationship between hepatitis B virus (HBV) infection and metabolic factors remains unclear. HBV infection is a health problem worldwide, especially in endemic regions such as Asia and Africa. It induces liver decompensation, cirrhosis, hepatocellualr carcinoma, and premature mortality. The prevalence of metabolic syndrome continues to increase in parallel with the epidemic of obesity, which is closely associated with the development of diabetes, cardiovascular disease, or even cancer. The systemic review shows that chronic HBV infection protects against instead of promotes fatty liver. The mechanism is possibly due to a lower frequency of dyslipidemia profile in patients with chronic HBV infection. The association of HBV with metabolic syndrome, insulin resistance, and the risk of arteriosclerosis is still inconclusive. In addition, obesity, diabetes, and metabolic syndrome may accelerate the progression of liver disease in patients with chronic HBV infection and synergistically induce cirrhosis or even hepatocellualr carcinoma development. ? 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919595063&doi=10.1111%2fjgh.12700&partnerID=40&md5=bab49ec7dc384f55dbc4cc0961c2ae79 https://scholars.lib.ntu.edu.tw/handle/123456789/581968 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12700 | SDG/Keyword: | lipid; arteriosclerosis; chronic hepatitis; diabetes mellitus; disease association; disease course; dyslipidemia; fatty liver; hepatitis B; Hepatitis B virus; human; insulin resistance; metabolic syndrome X; obesity; priority journal; Review; systematic review; Carcinoma, Hepatocellular; Cardiovascular Diseases; complication; hepatitis B; liver cirrhosis; Liver Neoplasms; metabolic syndrome X; obesity; prevalence; Carcinoma, Hepatocellular; Cardiovascular Diseases; Disease Progression; Hepatitis B, Chronic; Humans; Insulin Resistance; Liver Cirrhosis; Liver Neoplasms; Metabolic Syndrome X; Obesity; Prevalence |
Appears in Collections: | 臨床醫學研究所 |
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