https://scholars.lib.ntu.edu.tw/handle/123456789/593253
標題: | Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan | 作者: | CHUN-JEN LIU SHYH-CHYI LO JIA-HORNG KAO Tseng P.-T. Lai M.-Y. YEN-HSUAN NI Shiou-Hwei Yeh PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 2006 | 出版社: | Elsevier | 卷: | 44 | 期: | 1 | 起(迄)頁: | 39-46 | 來源出版物: | Journal of Hepatology | 摘要: | Background/Aims: The infectivity of occult hepatitis B virus (HBV), defined as HBsAg-negative but HBV DNA-positive, after transfusion has been low but not negligible. To address this, we investigated the incidence of post-transfusion HBV infection after receiving screened blood units in Taiwan. Methods: Consecutive HBV-na?ve (anti-HBc-negative) recipients with normal ALT were followed for HBV DNA and serologic markers before and after transfusion. Among 4448 blood recipients, 467 (10.5%) were anti-HBc-negative. Post-transfusion 6-month follow-up was completed for 327. We identified 5 (1.5%) who developed hepatitis B viremia 1 week after transfusion. Three were children who later seroconverted to anti-HBc but with normal ALT indicating subclinical acute infection, despite all had anti-HBs from previous vaccination. One had transient transfusion-transmitted HBV without seroconversion to anti-HBc and one possibly had occult HBV infection. Our findings suggested the possibility that occult HBV infection was transmissible by transfusion. The incidence of post-transfusion acute HBV infection was 0.9% (100 per million units) in na?ve recipients in Taiwan, a figure 7?40-fold higher than in developed countries. Moreover, some vaccinated children with anti-HBs were still susceptible. Conclusions: Therefore, despite active immunization, sensitive screening assays for occult HBV infection such as nucleic acid amplification test could be considered in endemic areas. ? 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984541353&doi=10.1016%2fj.jhep.2005.06.016&partnerID=40&md5=d18944f416f5e0fc48bb9974c2f1472c https://scholars.lib.ntu.edu.tw/handle/123456789/593253 |
ISSN: | 0168-8278 | DOI: | 10.1016/j.jhep.2005.06.016 | SDG/關鍵字: | alanine aminotransferase; virus DNA; adolescent; adult; article; blood transfusion; child; clinical article; controlled study; female; follow up; hepatitis B; Hepatitis B virus; human; incidence; male; priority journal; recipient; screening test; serology; Taiwan; vaccination; viremia; virus transmission |
顯示於: | 臨床醫學研究所 |
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