https://scholars.lib.ntu.edu.tw/handle/123456789/597030
標題: | The relationship between thyrotropin receptor antibody levels and intrathyroid vascularity in patients with graves' disease | 作者: | SHYANG-RONG SHIH Chang, J.-S. Lin, Lung-Chun YI-CHENG CHANG HUNG-YUAN LI Lee, C.-Y. CHUNG-MING CHEN TIEN-CHUN CHANG |
公開日期: | 2013 | 卷: | 121 | 期: | 1 | 起(迄)頁: | 1-5 | 來源出版物: | Experimental and Clinical Endocrinology and Diabetes | 摘要: | Objective: Thyroid stimulating hormone receptor antibodies (TSHRAbs) are specific autoantibodies of Graves' disease (GD). They activate adenylate cyclase, induce thyroid growth, and cause an increased rate of thyroid hormone production and secretion. TSHRAbs levels are decreased by treatment and may predict recurrence when they persist. Theoretically, TSHRAbs levels should be related to intrathyroid vascularity (ITV) due to the autoimmunity and inflammation. We aimed to analyze the relationship between TSHRAbs represented by thyrotropin-binding inhibitory immunoglobulin (TBII) levels and ITV measured by thyroid duplex sonography (TDS). Patients: 56 GD patients were prospectively recruited. Measurements: ITV, measured using TDS, was defined as follows: (average color-flow area in the right and left sides of the thyroid/total thyroid area in transverse view)×100. Results: The average TBII level was 47.1% and average ITV was 27.24. ITV positively and significantly correlated with TBII (p<0.001). Conclusions: TSHRAbs show significant correlation with ITV. This may help doctors to estimate thyroid autoimmune activity when they performing sonography at clinics. ? J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872616722&doi=10.1055%2fs-0031-1297992&partnerID=40&md5=2327954cb1cb9c033c958e388ef28147 https://scholars.lib.ntu.edu.tw/handle/123456789/597030 |
ISSN: | 0947-7349 | DOI: | 10.1055/s-0031-1297992 | SDG/關鍵字: | thyroid stimulating hormone receptor antibody; thyrotropin; thyrotropin receptor antibody; unclassified drug; adolescent; adult; article; autoimmunity; disease duration; echography; female; free thyroxine index; Graves disease; human; major clinical study; male; prevalence; priority journal; prospective study; smoking; thyroid gland; vascularization; Autoantibodies; Female; Graves Disease; Humans; Male; Receptors, Thyrotropin; Retrospective Studies; Thyroid Gland |
顯示於: | 基因體暨蛋白體醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。