https://scholars.lib.ntu.edu.tw/handle/123456789/597031
標題: | Preoperative prediction of papillary thyroid carcinoma prognosis with the assistance of computerized morphometry of cytology samples obtained by fine-needle aspiration: Preliminary report | 作者: | SHYANG-RONG SHIH YI-CHENG CHANG HUNG-YUAN LI JAU-YU LIAU Lee C.-Y. Chen C.-M. TIEN-CHUN CHANG |
公開日期: | 2013 | 卷: | 35 | 期: | 1 | 起(迄)頁: | 28-34 | 來源出版物: | Head and Neck | 摘要: | Background The purpose of this study was to analyze the relationship between cytologic features, clinical features, and recurrence of papillary thyroid cancer (PTC). We hoped to predict prognosis preoperatively. Methods We retrospectively studied cytologic features by using computerized morphometry and clinical data of 118 patients with usual-type PTC without initial metastasis, including 34 patients with cancer recurrence in 10 years after surgery and 84 patients who did not have recurrence for more than 10 years after surgery. Another 24 patients were recruited for validation. Results Multivariate logistic analysis indicated that nucleus-to-cell ratio, variation of nuclear area, tumor size, and patient age were significantly related to recurrence. Cox regression analysis showed that hazard ratios were 3.34, 1.53, 1.77, and 2.6, respectively. Conclusion Cytologic features of PTC analyzed with computerized morphometry significantly correlated with recurrence. It helped to predict prognosis preoperatively and may be helpful for planning further treatment. ? 2012 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871203445&doi=10.1002%2fhed.22909&partnerID=40&md5=a5b8904d73298a09a4ae236130962add https://scholars.lib.ntu.edu.tw/handle/123456789/597031 |
ISSN: | 1043-3074 | DOI: | 10.1002/hed.22909 | SDG/關鍵字: | adult; aged; article; cancer prognosis; cancer recurrence; cancer surgery; cell nucleus; computer; controlled study; cytology; female; human; major clinical study; male; metastasis; morphometrics; needle biopsy; preoperative period; priority journal; retrospective study; scoring system; thyroid carcinoma; tumor volume; Adolescent; Adult; Aged; Biopsy, Fine-Needle; Carcinoma; Cell Nucleus; Female; Humans; Male; Middle Aged; Preoperative Period; Prognosis; Recurrence; Regression Analysis; Retrospective Studies; Thyroid Gland; Thyroid Neoplasms; Young Adult |
顯示於: | 基因體暨蛋白體醫學研究所 |
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