https://scholars.lib.ntu.edu.tw/handle/123456789/607087
標題: | Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors | 作者: | Chen K.-T Chai W.-Y Lin Y.-J Lin C.-J Chen P.-Y Tsai H.-C Huang C.-Y Kuo J.S Wei K.-C. HAO-LI LIU |
關鍵字: | Tumors;Ultrasonics;Blood-brain barrier;Focused ultrasound;Immune modulation;Immunological response;Immunostimulation;Therapeutic agents;Therapeutic benefits;Tumor microenvironment;Blood | 公開日期: | 2021 | 卷: | 7 | 期: | 6 | 來源出版物: | Science Advances | 摘要: | Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to benefit recurrent glioblastoma (rGBM) treatment. This study is a dose-escalating pilot trial using a device combining neuronavigation and a manually operated frameless FUS system to treat rGBM patients. The safety and feasibility were established, while a dose-dependent BBB-opening effect was observed, which reverted to baseline within 24 hours after treatment. No immunological response was observed clinically under the applied FUS level in humans; however, selecting a higher level in animals resulted in prolonged immunostimulation, as confirmed preclinically by the recruitment of lymphocytes into the tumor microenvironment (TME) in a rat glioma model. Our findings provide preliminary evidence of FUS-induced immune modulation as an additional therapeutic benefit by converting the immunosuppressive TME into an immunostimulatory TME via a higher but safe FUS dosage. Copyright ? 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100971358&doi=10.1126%2fsciadv.abd0772&partnerID=40&md5=dc239765b0c5e94236b1c3c0ea8ee739 https://scholars.lib.ntu.edu.tw/handle/123456789/607087 |
ISSN: | 23752548 | DOI: | 10.1126/sciadv.abd0772 |
顯示於: | 電機工程學系 |
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