https://scholars.lib.ntu.edu.tw/handle/123456789/627769
標題: | The performance of risk scores and hemoglobin a1c to find undiagnosed diabetes with isolated postload hyperglycemia | 作者: | HUNG-YUAN LI MAO-SHIN LIN SHYANG-RONG SHIH Hua, Cyue Huei Liu, Yu Lai LEE-MING CHUANG Sung, Fung Chang MING-FONG CHEN Lee, Jin Chuan Chiao, Ching Hsiang Wei, Jung Nan |
關鍵字: | Impaired fasting glucose | Isolated postload hyperglycemia | Risk score | 公開日期: | 11-七月-2011 | 卷: | 58 | 期: | 6 | 來源出版物: | Endocrine Journal | 摘要: | The aim of this study is to develop strategies to screen diabetic subjects with isolated postload hyperglycemia (IPH) in Chinese population. We included 1175 adult subjects who did not report diabetes were included. Diabetes was diagnosed by oral glucose tolerance tests. IPH was defined as fasting plasma glucose (FPG)<7 mmol/L and 2-hour post-load plasma glucose (2hPG) greater than 11.1 mmol/L. Using FPG criteria, only 59.8% of diabetic subjects were not identified, showing a poor agreement between FPG and 2hPG criteria (kappa 0.294). Age, FPG, total cholesterol, triglycerides, blood pressure, body mass index, HbA1c and medication for hypertension were associated factors for IPH. Four scores were constructed using all these factors, age and blood test results, age and HbA1c, and data from non-invasive examinations, respectively. The area under the ROC curve were 0.9296(95%CI 0.8948-0.9643), 0.9111(95%CI 0.8713-0.9508), 0.8902(95%CI 0.8341- 0.9646), 0.8924(95%CI 0.7835-0.8753), and 0.8654(95%CI 0.7963-0.9345) for score 1, 2, 3, 4, and HbA1c, respectively. The sensitivity of all four risk scores to detect IPH was better than that of impaired fasting glucose (IFG). The sensitivity and specificity of HbA1c at cutoff 6.2% for detecting IPH was also better than that of IFG. In conclusion, the risk scores and HbA1c are useful to identify subjects with undiagnosed IPH, with better performance than IFG. ©The Japan Endocrine Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627769 | ISSN: | 09188959 | DOI: | 10.1507/endocrj.K11E-005 |
顯示於: | 醫學系 |
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