https://scholars.lib.ntu.edu.tw/handle/123456789/627807
標題: | Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice | 作者: | SHU-HUEI WANG FENG-CHIAO TSAI Lin, Heng-Huei Yu, Tse-Ya Kuo, Chun-Heng HUNG-YUAN LI MAO-SHIN LIN |
關鍵字: | Atheroscelrosis; Fatty liver; Monoamine oxidase B | 公開日期: | 13-一月-2023 | 出版社: | PORTLAND PRESS LTD | 卷: | 137 | 期: | 1 | 起(迄)頁: | 17 | 來源出版物: | Clinical science (London, England : 1979) | 摘要: | Oxidative stress is vital for pathophysiology of atherosclerosis and non-alcoholic fatty liver disease (NAFLD). Monoamine oxidase (MAO) is an important source of oxidative stress in the vascular system and liver. However, the effect of MAO inhibition on atherosclerosis and NAFLD has not been explored. In the present study, MAO A and B expressions were increased in atherosclerotic plaques in human and apolipoprotein E (ApoE)-deficient mice. Inhibition of MAO B (by deprenyl), but not MAO A (by clorgyline), reduced the atheroma area in the thoracic aorta and aortic sinus in ApoE-deficient mice fed the cholesterol-enriched diet for 15 weeks. MAO B inhibition attenuated oxidative stress, expression of adhesion molecules, production of inflammatory cytokines, and macrophage infiltration in atherosclerotic plaques and decreased plasma triglyceride and low-density lipoprotein (LDL) cholesterol concentrations. MAO B inhibition had no therapeutic effect on restenosis in the femoral artery wire-induced injury model in C57BL/6 mice. In the NAFLD mouse model, MAO B inhibition reduced lipid droplet deposition in the liver and hepatic total cholesterol and triglyceride levels in C57BL/6 mice fed high-fat diets for 10 weeks. Key enzymes for triglyceride and cholesterol biosynthesis (fatty acid synthase and 3-hydroxy-3-methylglutaryl-CoA reductase, HMGCR) and inflammatory markers were inhibited, and cholesterol clearance was up-regulated (increased LDL receptor expression and reduced proprotein convertase subtilisin/kexin type 9, PCSK9, expression) by MAO B inhibition in the liver. These results were also demonstrated in the HepG2 liver cell model. Our data suggest that MAO B inhibition is a potential and novel treatment for atherosclerosis and NAFLD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627807 | ISSN: | 0143-5221 | DOI: | 10.1042/CS20220477 |
顯示於: | 解剖學暨細胞生物學科所 |
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