https://scholars.lib.ntu.edu.tw/handle/123456789/629214
標題: | A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes | 作者: | JIN-YING LU Ou, Horng-Yih Wu, Chung-Ze Yang, Chwen-Yi Jiang, Ju-Ying Lu, Chieh-Hsiang YI-DER JIANG TIEN-JYUN CHANG YI-CHENG CHANG Hsieh, Meng-Lun WAN-CHEN WU HUNG-YUAN LI Du, Ye-Fong Lin, Ching-Han Hung, Hao-Chang Tien, Kai-Jen Yeh, Nai-Cheng Lee, Shang-Yu Yu, Hui-I LEE-MING CHUANG |
公開日期: | 15-二月-2023 | 卷: | 13 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Transcutaneous electrical nerve stimulator (TENS) has been demonstrated to be beneficial in glycemic control in animal models, but its application in humans has not been well studied. We randomly assigned 160 patients with type 2 diabetes on oral antidiabetic drugs 1:1 to the TENS study device (n = 81) and placebo (n = 79). 147 (92%) randomized participants (mean [SD] age 59 [10] years, 92 men [58%], mean [SD] baseline HbA1c level 8.1% [0.6%]) completed the trial. At week 20, HbA1c decreased from 8.1% to 7.9% in the TENS group (- 0.2% [95% CI - 0.4% to - 0.1%]) and from 8.1% to 7.8% in the placebo group (- 0.3% [95% CI - 0.5% to - 0.2%]) (P = 0.821). Glycemic variability, measured as mean amplitude of glycemic excursion (MAGE) at week 20 were significantly different in the TENS group vs. the placebo group (66 mg/dL [95% CI 58, 73] vs. 79 mg/dL [95% CI 72, 87]) (P = 0.009). Our study provides the clinical evidence for the first time in humans that TENS does not demonstrate a statistically significant HbA1c reduction. However, it is a safe complementary therapy to improve MAGE in patients with type 2 diabetes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629214 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-023-29791-7 |
顯示於: | 醫學系 |
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