https://scholars.lib.ntu.edu.tw/handle/123456789/484118
Title: | Fatal thrombocytopenia after oxaliplatin-based chemotherapy | Authors: | YU-YUN SHAO RUEY-LONG HONG |
Issue Date: | 2008 | Journal Volume: | 28 | Journal Issue: | 5 B | Start page/Pages: | 3115-3117 | Source: | Anticancer Research | Abstract: | Oxaliplatin-related thrombocytopenia is considered rare and mostly self-limited. We present the first reported fatal case due to this complication. A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin. Consciousness changed on the next evening and deteriorated to deep coma within hours. Computed tomography revealed large intracranial hemorrhage with brain herniation. Hemogram showed severe thrombocytopenia, which was considered to be associated with oxaliplatin. The patient died six days later. The incidence of oxaliplatin-related thrombocytopenia may have been underestimated and its severity long neglected. Other hypersensitivity reactions may precede its onset. Early hemogram examination during hypersensitivity reaction to oxaliplatin may provide early diagnosis and the prevention of the possible fatal consequences. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-55749096402&partnerID=40&md5=348c50d6e656abcbc818d5b1577daa55 https://scholars.lib.ntu.edu.tw/handle/123456789/484118 |
ISSN: | 0250-7005 | SDG/Keyword: | antihistaminic agent; fluorouracil; folinic acid; oxaliplatin; steroid; adult; article; brain hernia; case report; chill; colon cancer; computer assisted tomography; human; hypersensitivity reaction; incidence; male; priority journal; rash; thrombocytopenia; tremor; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Humans; Intracranial Hemorrhages; Male; Middle Aged; Organoplatinum Compounds; Thrombocytopenia |
Appears in Collections: | 腫瘤醫學研究所 |
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